Author:
Talwar Puneet,Deantoni Michele,Van Egroo Maxime,Muto Vincenzo,Chylinski Daphne,Koshmanova Ekaterina,Jaspar Mathieu,Meyer Christelle,Degueldre Christian,Berthomier Christian,Luxen André,Salmon Eric,Collette Fabienne,Dijk D.-J.,Schmidt Christina,Phillips Christophe,Maquet Pierre,Sherif Siya,Vandewalle Gilles
Abstract
AbstractThe regional integrity of brain subcortical structures has been implicated in sleep–wake regulation, however, their associations with sleep parameters remain largely unexplored. Here, we assessed association between quantitative Magnetic Resonance Imaging (qMRI)-derived marker of the myelin content of the brainstem and the variability in the sleep electrophysiology in a large sample of 18-to-31 years healthy young men (N = 321; ~ 22 years). Separate Generalized Additive Model for Location, Scale and Shape (GAMLSS) revealed that sleep onset latency and slow wave energy were significantly associated with MTsat estimates in the brainstem (pcorrected ≤ 0.03), with overall higher MTsat value associated with values reflecting better sleep quality. The association changed with age, however (MTsat-by-age interaction—pcorrected ≤ 0.03), with higher MTsat value linked to better values in the two sleep metrics in the younger individuals of our sample aged ~ 18 to 20 years. Similar associations were detected across different parts of the brainstem (pcorrected ≤ 0.03), suggesting that the overall maturation and integrity of the brainstem was associated with both sleep metrics. Our results suggest that myelination of the brainstem nuclei essential to regulation of sleep is associated with inter-individual differences in sleep characteristics during early adulthood. They may have implications for sleep disorders or neurological diseases related to myelin.
Funder
Fonds De La Recherche Scientifique—FNRS
UK Dementia Research Institute
Fédération Wallonie-Bruxelles
Walloon excellence in life sciences and biotechnology
Fondation pour la Recherche sur Alzheimer
Université de Liège
Fondation Simone et Pierre Clerdent
European Regional Development Fund
Fonds Léon Fredericq
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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