Author:
Tian Ran,Wu Wei,Wang Chunyao,Pang Haiyu,Zhang Zhiyu,Xu Haopeng,Luo Qingfeng,Gao Peng,Shi Jihua,Li Wenbin,Qian Hao,Guo Fan,Li Taisheng,Liu Zhengyin,Wang Jinglan,Zhou Xiang,Qin Yan,Yan Xiaowei,Zhang Shuyang
Abstract
AbstractSince the outbreak of COVID-19 in China at the end of 2019, the world has experienced a large-scale epidemic caused by the SARS-CoV-2. The epidemiological and clinical course of COVID-19 patients has been reported, but there have been few analyses about the characteristics, predictive risk factors, and outcomes of critical patients. In this single-center retrospective case–control study, 90 adult inpatients hospitalized at Tongji Hospital (Wuhan, China) were included. Demographic, clinical, laboratory tests, and treatment data were obtained and compared between critical and non-critical patients. We found that compared with non-critical patients, the critical patients had higher SOFA score and qSOFA scores. Critical patients had lower lymphocyte and platelet count, elevated D-dimer, decreased fibrinogen, and elevated high-sensitivity C-reactive protein (hsCRP), and interleukin-6(IL-6). More critical patients received treatment including antibiotics, anticoagulation, corticosteroid, and oxygen therapy than non-critical ones. Multivariable regression showed higher qSOFA score and elevation of IL-6 were related to critical patients. Antibiotic usage and anticoagulation were associated with decreased in-hospital mortality. And critical grouping contributed greatly to in-hospital death. Critical COVID-19 patients have a more severe clinical course. qSOFA score and elevation of IL-6 are risk factors for critical condition. Non-critical grouping, positive antibiotic application, and anticoagulation may be beneficial for patient survival.
Funder
Chinese Academy of Medical Sciences
Publisher
Springer Science and Business Media LLC
Reference18 articles.
1. Nation Health Commission of China. Update on COVID-19. https://www.nhc.gov.cn/yjb/s7860/202008/34a1d6028a3449d0b2c2679c5d8e3b1b.shtml (2020).
2. WHO. WHO Coronavirus Disease (COVID-19) Dashboard - 25 August 2020. https://covid19.who.int/ (2020).
3. WHO. WHO director general's opening remarks at the media briefing on covid-19—11 march 2020, https://www.who.int/zh/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11-march-2020 (2020).
4. Nation Health Commission of China. Guidelines for diagnosis and treatment of COVID-19 (7th ed), https://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml (2020).
5. Wang, D. et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA https://doi.org/10.1001/jama.2020.1585 (2020).
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献