Author:
Lo Shih-Chiang,You Chao-Xuan,Chen Bo-Ren,Hsieh Ching-Chu,Li Cheng-En,Shu Che-Chi
Abstract
AbstractThere is a special node, which the large noise of the upstream element may not always lead to a broad distribution of downstream elements. This node is DNA, with upstream element TF and downstream elements mRNA and proteins. By applying the stochastic simulation algorithm (SSA) on gene circuits inspired by the fim operon in Escherichia coli, we found that cells exchanged the distribution of the upstream transcription factor (TF) for the transitional frequency of DNA. Then cells do an inverse transform, which exchanges the transitional frequency of DNA for the distribution of downstream products. Due to this special feature, DNA in the system of frequency modulation is able to reset the noise. By probability generating function, we know the ranges of parameter values that grant such an interesting phenomenon.
Funder
Ministry of Science and Technology, Taiwan
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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