Author:
Tsutsumi Akihiro,Chubachi Shotaro,Irie Hidehiro,Sasaki Mamoru,Yamada Yoshitake,Sugiura Hiroaki,Jinzaki Masahiro,Nakamura Hidetoshi,Asano Koichiro,Betsuyaku Tomoko,Fukunaga Koichi
Abstract
AbstractEmphysema is a major pathological change in chronic obstructive pulmonary disease (COPD). However, the annual changes in the progression of emphysematous have not been investigated. We aimed to determine possible baseline predicting factors of the change in emphysematous progression in a subgroup of COPD patients who demonstrated rapid progression. In this observational study, we analyzed patients with COPD who were followed up by computed tomography (CT) at least two times over a 3-year period (n = 217). We divided the annual change in the low attenuation area percentage (LAA%) into quartiles and defined a rapid progression group (n = 54) and a non-progression group (n = 163). Predictors of future changes in emphysematous progression differed from predictors of high LAA% at baseline. On multivariate logistic regression analysis, low blood eosinophilic count (odds ratio [OR], 3.22; P = 0.04) and having osteoporosis (OR, 2.13; P = 0.03) were related to rapid changes in emphysematous progression. There was no difference in baseline nutritional parameters, but nutritional parameters deteriorated in parallel with changes in emphysematous progression. Herein, we clarified the predictors of changes in emphysematous progression and concomitant deterioration of nutritional status in COPD patients.
Publisher
Springer Science and Business Media LLC
Reference56 articles.
1. Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management and prevention of COPD (2019 Report). Fontana, WI: Global Initiative for Chronic Obstructive Lung Disease (GOLD). https://goldcopd.org/wp-content/uploads/2018/11/GOLD-2019-v1.7-FINAL-14Nov2018-WMS.pdf. Accessed March 25 2019.
2. Snider, G. L., Kleinerman, J., Thurlbeck, W. M. & Bengali, Z. H. The definition of emphysema. Report of a national heart, lung, and blood institute, division of lung diseases workshop. Am. Rev. Respir. Dis. 132, 182–185 (1985).
3. Makita, H. et al. Characterization of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. Thorax 62, 932–937 (2007).
4. Gould, G. A. et al. CT measurements of lung density in life can quantitate distal airspace enlargement–an essential defining feature of human emphysema. Am. Rev. Respir. Dis. 137, 380–392 (1988).
5. Nishimura, M. et al. Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 185, 44–52 (2012).
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献