Author:
Lehrach Hans,Curtis Jon,Lange Bodo,Ogilvie Lesley A.,Gauss Richard,Steininger Christoph,Scholz Erhard,Kreck Matthias
Abstract
AbstractOur lives (and deaths) have by now been dominated for two years by COVID-19, a pandemic that has caused hundreds of millions of disease cases, millions of deaths, trillions in economic costs, and major restrictions on our freedom. Here we suggest a novel tool for controlling the COVID-19 pandemic. The key element is a method for a population-scale PCR-based testing, applied on a systematic and repeated basis. For this we have developed a low cost, highly sensitive virus-genome-based test. Using Germany as an example, we demonstrate by using a mathematical model, how useful this strategy could have been in controlling the pandemic. We show using real-world examples how this might be implemented on a mass scale and discuss the feasibility of this approach.
Funder
Alacris Theranostics
City Government, Vienna
Medizinische Universität Wien
Max Planck Institute for Molecular Genetics
Publisher
Springer Science and Business Media LLC
Reference35 articles.
1. Lehrach, H. & Church, G. Unser Weg aus der Pandemie. https://www.faz.net/aktuell/wissen/medizin-ernaehrung/schnellerer-test-fuer-sars-cov-2-unser-weg-aus-der-pandemie-16776309.html (2020)
2. Taipale, J., Romer, P. & Linnarson, S. Population-scale testing can suppress the spread of COVID-19. Preprint at medXriv https://doi.org/10.1101/2020.04.27.20078329 (2020).
3. Moses, S. et al. Endpoint PCR detection of Sars-CoV-2 RNA. Preprint at medXriv https://doi.org/10.1101/2020.07.21.20158337 (2020).
4. Mercer, T. R. & Salit, M. Testing at scale during the COVID-19 pandemic. Nat. Rev. Genet. 22, 415–426 (2021).
5. The COVID-19 testing debacle. Nat. Biotechnol. 38, 653 (2020).
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献