Author:
Torres-Sánchez Pablo,Porras Ignacio,Ramos-Chernenko Nataliya,Arias de Saavedra Fernando,Praena Javier
Abstract
AbstractBoron Neutron Capture Therapy (BNCT) is facing a new era where different projects based on accelerators instead of reactors are under development. The new facilities can be placed at hospitals and will increase the number of clinical trials. The therapeutic effect of BNCT can be improved if a optimized epithermal neutron spectrum is obtained, for which the beam shape assembly is a key ingredient. In this paper we propose an optimal beam shaping assembly suited for an affordable low energy accelerator. The beam obtained with the device proposed accomplishes all the IAEA recommendations for proton energies between 2.0 and 2.1 MeV. In addition, there is an overall improvement of the figures of merit with respect to BNCT facilities and previous proposals of new accelerator-based facilities.
Funder
Ministry of Science, Innovation and Universities, Spain
Junta de Andalucía
Fundación ACS
La Kuadrilla de Iznalloz
Capitán Antonio
Sonriendo se Puede Ganar
European Social Fund
Publisher
Springer Science and Business Media LLC
Reference36 articles.
1. Barth, R. F. et al. Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer. Radiat. Oncol. 7, 1–21. https://doi.org/10.1186/1748-717X-7-146 (2012).
2. Kreiner, A. J. et al. Present status of accelerator-based BNCT. Rep. Pract. Oncol. Radiother. 21, 95–101. https://doi.org/10.1016/j.rpor.2014.11.004 (2016) (7th Young BNCT meeting).
3. Porras, I. et al. Proceedings of the 15th International Conference on Nuclear Reaction Mechanisms, chap. Perspectives on Neutron Capture Therapy of Cancer, 295–304 (CERN, Geneva, 2018). https://doi.org/10.23727/CERN-Proceedings-2019-001.
4. Sakurai, Y. Progress in Reactor and accelerator based BNCT at Kyoto University Research Reactor Institute. Proceedings of Science INPC2016, 127 (2017). https://doi.org/10.22323/1.281.0127.
5. Current Status of Neutron Capture Therapy. No. 1223 in TECDOC Series (International Atomic Energy Agency, 2001). https://www.iaea.org/publications/6168/current-status-of-neutron-capture-therapy.
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