Disruption of key NADH-binding pocket residues of the Mycobacterium tuberculosis InhA affects DD-CoA binding ability
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-05042-4.pdf
Reference32 articles.
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2. Vilchèze, C. et al. Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid. Nat Med 12, 1027–1029 (2006).
3. Gandhi, N. R., Nunn, P., Dheda, K., Schaaf, H. S. & Zignol, M. Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis. The Lancet 22, 1830–1843 (2010).
4. Zumla, A. I. et al. New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects. The Lancet Infectious Diseases 14, 327–340 (2014).
5. Marrakchi, H., Lanéelle, M.-A. & Daffé, M. Mycolic acids: structures, biosynthesis, and beyond. Chemistry & Biology 21, 67–85 (2014).
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