In platelet single donor apheresis, platelet factor 4 levels correlated with donor’s age and decreased during storage-Reference-Cited by-同舟云学术

In platelet single donor apheresis, platelet factor 4 levels correlated with donor’s age and decreased during storage

Published:2024-03-14 Issue:1 Volume:14 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Duchez Anne Claire,Heestermans Marco,Arthaud Charles-Antoine,Eyraud Marie-Ange,Portier Mailys,Prier Amélie,Hamzeh-Cognasse Hind,Cognasse Fabrice

Abstract

AbstractThe human population is ageing worldwide. The World Health Organization estimated that the world’s population of people aged 60 years and older will increase to at least 30%, coinciding with a growing frequency of cognitive and cardiovascular disease. Recently, in preclinical studies platelet Factor 4 (PF4) was presented as a pro-cognitive factor. This molecule is released by platelets in the circulation and could be present in blood products destined for transfusion. We wondered if PF4 levels are correlated to the age of the blood donor or to the storage time of platelet concentrates (PCs) intended for transfusion? We observed higher levels of PF4 in PCs from elderly donors compared to younger donors, while PC storage time did not determine PF4 levels expression.

Funder

Etablissement Français du Sang

Agence Nationale de la Recherche

Association “Les Amis de Rémi” Savigneux, France

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41598-024-56826-4.pdf

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