Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-12750-4.pdf
Reference56 articles.
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3. Miller, J. F. The discovery of thymus function and of thymus-derived lymphocytes. Immunol Rev 185, 7–14 (2002).
4. Buckley, R. H. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annual review of immunology 22, 625–655, https://doi.org/10.1146/annurev.immunol.22.012703.104614 (2004).
5. Puck, J. M. et al. The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1. Hum Mol Genet 2, 1099–1104 (1993).
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