Author:
Nagasato Daisuke,Muraoka Yuki,Osaka Rie,Iida-Miwa Yuko,Mitamura Yoshinori,Tabuchi Hitoshi,Kadomoto Shin,Murakami Tomoaki,Ooto Sotaro,Suzuma Kiyoshi,Tsujikawa Akitaka
Abstract
AbstractHere, we examined prognostic factors for extremely poor visual outcomes in patients with central retinal vein occlusion (CRVO) in actual practices. We included 150 consecutive eyes with treatment-naïve acute CRVO from four different facilities and observed them for over 24 months. Macular edema (ME) was treated with one or three monthly anti-vascular endothelial growth factor injections (1 or 3 + pro re nata). According to the final Snellen visual acuity (VA), we divided the patients into very poor VA (< 20/200) and control (≥ 20/200) groups and examined risk factors for poor final visual outcomes. The baseline Snellen VA was hand motion to 20/13. The mean number of anti-VEGF injections for ME was 5.3 ± 3.7 during the follow-up period. In total, 49 (32.7%) patients exhibited a very poor final VA; this group comprised significantly older patients with a significantly poorer baseline VA (P < 0.01 for both) than the control group. Comorbid internal carotid artery disease and diabetic retinopathy were significantly associated with a poor final VA. In actual clinical practice, visual outcomes may be extremely poor despite ME treatment in certain patients with CRVO, with advanced age, poor baseline VA, and comorbid internal carotid artery disease and diabetic retinopathy being significant risk factors.
Funder
the Japan Society for the Promotion of Science (JSPS), Tokyo, Japan (Grant-in-Aid for Scientific Researc
Novartis Pharma K.K.
the Innovative Techno-Hub for Integrated Medical Bio-Imaging of the Project for Developing Innovation Systems, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
Publisher
Springer Science and Business Media LLC
Cited by
12 articles.
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