Author:
Aoki Yasunori,Kazui Hiroaki,Bruña Ricardo,Pascual-Marqui Roberto D.,Yoshiyama Kenji,Wada Tamiki,Kanemoto Hideki,Suzuki Yukiko,Suehiro Takashi,Matsumoto Takuya,Kakeda Kyosuke,Hata Masahiro,Canuet Leonides,Ishii Ryouhei,Iwase Masao,Ikeda Manabu
Abstract
AbstractIdiopathic normal pressure hydrocephalus (iNPH) is a neuropsychiatric disease characterized by gait disturbance, cognitive deterioration and urinary incontinence associated with excessive accumulation of cerebrospinal fluid (CSF) in the brain ventricles. These symptoms, in particular gait disturbance, can be potentially improved by shunt operation in the early stage of the disease, and the intervention associates with a worse outcome when performed late during the course of the disease. Despite the variable outcome of shunt operation, noninvasive presurgical prediction methods of shunt response have not been established yet. In the present study, we used normalized power variance (NPV), a sensitive measure of the instability of cortical electrical activity, to analyze cortical electrical activity derived from EEG data using exact-low-resolution-electromagnetic-tomography (eLORETA) in 15 shunt responders and 19 non-responders. We found that shunt responders showed significantly higher NPV values at high-convexity areas in beta frequency band than non-responders. In addition, using this difference, we could discriminate shunt responders from non-responders with leave-one-subject-out cross-validation accuracy of 67.6% (23/34) [positive predictive value of 61.1% (11/18) and negative predictive value of 75.0% (12/16)]. Our findings indicate that eLORETA-NPV can be a useful tool for noninvasive prediction of clinical response to shunt operation in patients with iNPH.
Funder
Japan Society for the Promotion of Science
Japanese Ministry of Health, Labour and Welfare
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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