Author:
Carvalho Lucas Rannier Ribeiro Antonino,Boeder Ariela M.,Shimari Miho,Kleschyov Andrei L.,Esberg Anders,Johansson Ingegerd,Weitzberg Eddie,Lundberg Jon O.,Carlstrom Mattias
Abstract
AbstractProlonged use of antibacterial mouthwash is linked to an increased risk of systemic disease. We aimed to investigate if disturbing the oral microbiota would impact the lower gut microbiome with functional effects in diet-induced obesity. Mice were exposed to oral chlorhexidine and fed a Western diet (WD). Food intake and weight gain were monitored, and metabolic function, blood pressure, and microbiota were analyzed. Chlorhexidine reduced the number of viable bacteria in the mouth and lowered species richness in the gut but with proportional enrichment of some bacteria linked to metabolic pathways. In mice fed a Western diet, chlorhexidine reduced weight gain, body fat, steatosis, and plasma insulin without changing caloric intake, while increasing colon triglycerides and proteins, suggesting reduced absorption of these nutrients. The mechanisms behind these effects as well as the link between the oral microbiome and small intestinal function need to be pinpointed. While the short-term effects of chlorhexidine in this model appear beneficial, potential long-term disruptions in the oral and gut microbiota and possible malabsorption should be considered.
Funder
Vetenskapsrådet
Hjärt-Lungfonden
Stockholm City Council
Novo Nordisk Fonden
Swedish Foundation for International Cooperation in Research and Higher Education
Karolinska Institutet
Karolinska Institute
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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