Author:
Chen Lina,Gao Zhenhua,Zhang Ye,Dai Xiandong,Meng Fanhua,Guo Yongbiao
Abstract
AbstractCapsaicin derivatives with thiourea structure (CDTS) is highly noteworthy owing to its higher analgesic potency in rodent models and higher agonism in vitro. However, the direct synthesis of CDTS remains t one or more shortcomings. In this study, we present reported a green, facile, and practical synthetic method of capsaicin derivatives with thiourea structure is developed by using an automated synthetic system, leading to a series of capsaicin derivatives with various electronic properties and functionalities in good to excellent yields.
Publisher
Springer Science and Business Media LLC
Reference27 articles.
1. Kosuge, S. & Furuta, M. Studies on the pungent principle of capsicum part XIV chemical constitution of the pungent principle. Agric. Boi. Chem. 34, 248–256 (1970).
2. Sawynok, J. Topical analgesics in neuropathic pain. Curr. Pharm. Des. 2005(11), 2995–3004 (2005).
3. Peppin, J. F. et al. Tolerability of NGX-4010, a capsaicin 8% patch for peripheral neuropathic pain. J. Pain. Res. 4, 385–392 (2011).
4. Webster, L. R., Tobias, J. K. & Vanhove, G. F. Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic pain. Diabetes Res. Clin. Pract. 93, 187–197 (2011).
5. Mason, L., Moore, R. A., Derry, S., Edwards, J. E. & McQuay, H. J. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ. 328, 991 (2004).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献