Author:
Manimaran Dharmar,Elangovan Namasivayam,Mani Panagal,Subramanian Kumaran,Ali Daoud,Alarifi Saud,Palanisamy Chella Perumal,Zhang Hongxia,Rangasamy Kowsalya,Palanisamy Vasan,Mani Renuka,Govarthanan Kavitha,Aruni Wilson,Shanmugam Rajeshkumar,Srinivasan Guru Prasad,Kalirajan Aruncahllam
Abstract
AbstractRecent breakthroughs in the field of nanoparticle-based therapeutic delivery methods have changed the standpoint of cancer therapy by effectively delaying the process of disease development. Nanoparticles have a unique capacity of good penetrating ability than other therapeutic leads used in traditional therapeutics, and also, they have the highest impact on disease management. In the current study isolongifolene-loaded Chitosan nanoparticles have been formulated, synthesized and then characterized by the use of Fourier Transform Infrared Spectroscopy, X-ray Diffraction, Scanning Electron Microscopy and Transmission Electron Microscopy. Further, the characterized chitosan nano formulation was evaluated for hemocompatibility, plasma stability, and in-vitro release. Isolongifolene-loaded chitosan nanoparticles were found to be compatible with plasma and also, they exhibited a constant release pattern. Hence, chitosan-loaded nanoparticles could be employed as an excellent adjuvant in cancer therapeutic, to combat the multi-drug resistance in solid tumors.
Publisher
Springer Science and Business Media LLC
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