Author:
Mercier Elisabeth,D’Aoust Patrick M.,Thakali Ocean,Hegazy Nada,Jia Jian-Jun,Zhang Zhihao,Eid Walaa,Plaza-Diaz Julio,Kabir Md Pervez,Fang Wanting,Cowan Aaron,Stephenson Sean E.,Pisharody Lakshmi,MacKenzie Alex E.,Graber Tyson E.,Wan Shen,Delatolla Robert
Abstract
AbstractRecurrent influenza epidemics and pandemic potential are significant risks to global health. Public health authorities use clinical surveillance to locate and monitor influenza and influenza-like cases and outbreaks to mitigate hospitalizations and deaths. Currently, global integration of clinical surveillance is the only reliable method for reporting influenza types and subtypes to warn of emergent pandemic strains. The utility of wastewater surveillance (WWS) during the COVID-19 pandemic as a less resource intensive replacement or complement for clinical surveillance has been predicated on analyzing viral fragments in wastewater. We show here that influenza virus targets are stable in wastewater and partitions favorably to the solids fraction. By quantifying, typing, and subtyping the virus in municipal wastewater and primary sludge during a community outbreak, we forecasted a citywide flu outbreak with a 17-day lead time and provided population-level viral subtyping in near real-time to show the feasibility of influenza virus WWS at the municipal and neighbourhood levels in near real time using minimal resources and infrastructure.
Funder
Ontario Ministry of Environment, Conservation and Parcs
Publisher
Springer Science and Business Media LLC
Cited by
57 articles.
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