Author:
Bouzo Belén L.,Lores Saínza,Jatal Raneem,Alijas Sandra,Alonso María José,Conejos-Sánchez Inmaculada,de la Fuente María
Abstract
AbstractColorectal cancer is the third most frequently diagnosed cancer malignancy and the second leading cause of cancer-related deaths worldwide. Therefore, it is of utmost importance to provide new therapeutic options that can improve survival. Sphingomyelin nanosystems (SNs) are a promising type of nanocarriers with potential for association of different types of drugs and, thus, for the development of combination treatments. In this work we propose the chemical modification of uroguanylin, a natural ligand for the Guanylyl Cyclase (GCC) receptor, expressed in metastatic colorectal cancer tumors, to favour its anchoring to SNs (UroGm-SNs). The anti-cancer drug etoposide (Etp) was additionally encapsulated for the development of a combination strategy (UroGm-Etp-SNs). Results from in vitro studies showed that UroGm-Etp-SNs can interact with colorectal cancer cells that express the GCC receptor and mediate an antiproliferative response, which is more remarkable for the drugs in combination. The potential of UroGm-Etp-SNs to treat metastatic colorectal cancer cells was complemented with an in vivo experiment in a xenograft mice model.
Funder
Axencia Galega de Innovación (GAIN), Consellería de Educación, Universidade e Formación Profesional
Instituto de Salud Carlos III (ISCIII), European Regional Development Fund
Publisher
Springer Science and Business Media LLC
Cited by
14 articles.
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