Allosteric inhibitor remotely modulates the conformation of the orthestric pockets in mutant IDH2/R140Q
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-16427-w.pdf
Reference44 articles.
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3. Dang, L., Jin, S. & Su, S. M. IDH mutations in glioma and acute myeloid leukemia. Trends Mol. Med. 16, 387–397 (2010).
4. Kao, H. W., Liang, D. C. & Wu, J. H. et al. Gene mutation patterns in patients with minimally differentiated acute myeloid leukemia. Neoplasia 16, 481–488 (2014).
5. Cairns, R. A., Iqbal, J. & Lemonnier, F. et al. IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma. Blood 119, 1901–1903 (2012).
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