Author:
Morita Kazuya,Matsumoto Naoyuki,Saito Kengo,Hamabe-Horiike Toshihide,Mizuguchi Keishi,Shinmyo Yohei,Kawasaki Hiroshi
Abstract
AbstractAquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under pathological conditions have been intensively investigated, those under normal physiological conditions are not fully understood. Here we demonstrate that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development. BMP signaling was preferentially activated in AQP4-positive astrocytes. Furthermore, activation of BMP signaling by in utero electroporation markedly increased AQP4 levels in the cerebral cortex, and inhibition of BMP signaling strongly suppressed them. These results indicate that BMP signaling alters AQP4 levels in the mouse cerebral cortex during development.
Funder
Ministry of Education, Culture, Sports, Science and Technology
Takeda Science Foundation
Uehara Memorial Foundation
Japan Agency for Medical Research and Development
Naito Foundation
Kanazawa University
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
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