Author:
Yamamoto Michiro,Yasunaga Hideo,Kakinoki Ryosuke,Tsubokawa Naoto,Morita Akimasa,Tanaka Katsumi,Sakai Akinori,Kurahashi Toshikazu,Hirata Hitoshi,Hirata Hitoshi,Tatebe Masahiro,Yamamoto Michiro,Onishi Tetsuro,Iwatsuki Katsuyuki,Tokutake Katsuhiro,Yasunaga Hideo,Kakinoki Ryosuke,Otani Kazuhiro,Tsubokawa Naoto,Morita Akimasa,Tanaka Katsumi,Sakai Akinori,Menuki Kunitaka,Yamanaka Yoshiaki,Urata Shiro,Oguchi Takeshi,Kurahashi Toshikazu,Iwasaki Norimasa,Matsui Yuichiro,Ikegami Hiroyasu,Sakano Hiroaki,Katsumura Tetsu,Nishiwaki Masao,Tanaka Toshikazu,Hirase Yuichi,Kanno Yuri,Kato Hiroyuki,Hayashi Masanori,Omokawa Shohei,Hasegawa Hideo,Gotani Hiroyuki,Tanaka Yoshitaka,Sunagawa Toru,Shinomiya Rikuo,Kajiwara Rhoji,Nakao Etsuhiro,Nishizuka Takanobu,Hattori Yasunori,Shinohara Takaaki,Watanabe Kentaro,Okui Nobuyuki,Koshima Hiroshi,Tajika Tsuyoshi,Ohi Hiroyuki,Kaji Yoshio,Nagayoshi Eiichi,Igarashi Ataru,
Abstract
AbstractThis study compared hand function and the cost-effectiveness of treatment between collagenase Clostridium histolyticum (CCH) injection and limited fasciectomy for patients with Dupuytren’s contracture (DC). The CeCORD-J study is a prospective, multicenter, non-randomized controlled, observational study of two parallel groups. Participants were DC patients with multiple affected fingers, including flexion contracture of the proximal interphalangeal (PIP) joint. The primary outcome was the Hand10 score, as a patient-reported outcome measure (PROM). We set secondary outcomes of EQ-5D-5L (QOL) score, degree of extension deficit, and direct cost. Propensity score adjustment was used to balance differences in patient characteristics between groups. Participants comprised 52 patients in the Collagenase group and 26 patients in the Surgery group. There were no significant differences in the Hand10 and QOL scores between the two groups at 26 weeks. Mean direct cost was 248,000 yen higher in the Surgery group than in the Collagenase group. Extension deficit angle of the PIP joint was significantly larger in the Collagenase group at 26 weeks. Although the Collagenase group showed dominance in cost-effectiveness, there was no significant difference between the two groups in hand function at 26 weeks.
Funder
This study was supported by Asahi Kasei Pharma Corporation.
Publisher
Springer Science and Business Media LLC