Author:
Gourgue Florian,Derouane Françoise,van Marcke Cedric,Villar Elodie,Dano Helene,Desmet Lieven,Bouzin Caroline,Duhoux Francois P.,Cani Patrice D.,Jordan Bénédicte F.
Abstract
AbstractObesity is a known factor increasing the risk of developing breast cancer and reducing disease free survival. In addition to these well-documented effects, recent studies have shown that obesity is also affecting response to chemotherapy. Among the multiple dysregulations associated with obesity, increased level of the apelin adipokine has been recently shown to be directly involved in the association between obesity and increased breast cancer progression. In this study, we analyzed in a retrospective cohort of 62 breast cancer patients the impact of obesity and tumoral apelin expression on response to neoadjuvant chemotherapy. In the multivariate logistic regression, obesity and high tumoral apelin expression were associated with a reduced response to NAC in our cohort. However, obesity and high tumoral apelin expression were not correlated, suggesting that those two parameters could be independently associated with reduced NAC response. These findings should be confirmed in independent cohorts.
Funder
Fonds De La Recherche Scientifique - FNRS
Cliniques Universitaires Saint-Luc
Fondation contre le Cancer
Publisher
Springer Science and Business Media LLC
Cited by
10 articles.
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