Author:
Lee Min-Yong,Son Minsoo,Lee Hyun Haeng,Kang Min-Gu,Yun Seo Jung,Seo Han Gil,Kim Youngsoo,Oh Byung-Mo
Abstract
AbstractSome individuals with mild traumatic brain injury (mTBI), also known as concussion, have neuropsychiatric and physical problems that last longer than a few months. Symptoms following mTBI are not only impacted by the kind and severity of the injury but also by the post-injury experience and the individual's responses to it, making the persistence of mTBI particularly difficult to predict. We aimed to identify prognostic blood-based protein biomarkers predicting 6-month outcomes, in light of the clinical course after the injury, in a longitudinal mTBI cohort (N = 42). Among 420 target proteins quantified by multiple-reaction monitoring-mass spectrometry assays of blood samples, 31, 43, and 15 proteins were significantly associated with the poor recovery of neuropsychological symptoms at < 72 h, 1 week, and 1 month after the injury, respectively. Sequential associations among clinical assessments (depressive symptoms and cognitive function) affecting the 6-month outcomes were evaluated. Then, candidate biomarker proteins indirectly affecting the outcome via neuropsychological symptoms were identified. Using the identified proteins, prognostic models that can predict the 6-month outcome of mTBI were developed. These protein biomarkers established in the context of the clinical course of mTBI may have potential for clinical application.
Funder
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Reference73 articles.
1. Dewan, M. C. et al. Estimating the global incidence of traumatic brain injury. J. Neurosurg. 130, 1–18 (2018).
2. Centers for Disease Control and Prevention & National Center for Health Statistics. Multiple cause of death 1999–2019 on CDC wonder online database, released in 2020. https://wonder.cdc.gov/wonder/help/mcd.html (2020).
3. Cuthbert, J. P. et al. Unemployment in the United States after traumatic brain injury for working-age individuals: Prevalence and associated factors 2 years postinjury. J. Head Trauma Rehabil. 30, 160–174 (2015).
4. Levin, H. S. & Diaz-Arrastia, R. R. Diagnosis, prognosis, and clinical management of mild traumatic brain injury. Lancet Neurol. 14, 506–517 (2015).
5. Carroll, L. J. et al. Prognosis for mild traumatic brain injury: Results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J. Rehabil. Med. 43, 84–105 (2004).