Author:
Nishi Akinori,Kaifuchi Noriko,Shimobori Chika,Ohbuchi Katsuya,Iizuka Seiichi,Sugiyama Aiko,Ogura Keisuke,Yamamoto Masahiro,Kuroki Haruo,Nabeshima Shigeki,Yachie Ayako,Matsuoka Yukiko,Kitano Hiroaki
Abstract
AbstractMaoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasally infected with influenza virus [A/PR/8/34 (H1N1)], maoto significantly improved survival rate, decreased viral titer, and ameliorated the infection-induced phenotype as compared with control mice. Analysis of the lung and plasma transcriptome and lipid mediator metabolite profile showed that maoto altered the profile of lipid mediators derived from ω-6 and ω-3 fatty acids to restore a normal state, and significantly up-regulated the expression of macrophage- and T-cell-related genes. Collectively, these results suggest that maoto regulates the host’s inflammatory response by altering the lipid mediator profile and thereby ameliorating the symptoms of influenza.
Publisher
Springer Science and Business Media LLC
Cited by
6 articles.
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