Author:
Proniewicz Edyta,Burnat Grzegorz,Domin Helena,Iłowska Emilia,Roman Adam,Prahl Adam
Abstract
AbstractEleven multiple analogs of bradykinin—a peptide that is a natural ligand of B1 and B2 receptors but does not bind or activate the B1 receptor unless Arg9 is removed from the sequence by the action of carboxypeptidase N—were synthesized. Their biological activity was examined on T-REx cell lines expressing B1 or B2 receptors using the intracellular IP1 assay. The mRNA expression of B1R and B2R in the lysate of tumor cell lines, e.g., U87-MG (human astrocytoma), SHP-77 (human small cell lung cancer), and H4 (human brain glioma), was determined. For five B1R antagonists, adsorption at the liquid/solid interface (Au nanoparticles (AuNPs) served as the solid surface) was discussed in terms of the vibrations of molecular fragments (structural factors) responsible for the biological properties of these analogs.
Funder
Narodowe Centrum Nauki
Akademia Górniczo-Hutnicza im. Stanislawa Staszica
Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk
Publisher
Springer Science and Business Media LLC
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