Author:
Okuda Koichi,Nakajima Kenichi,Kitamura Chiemi,Kirihara Yumiko,Hashimoto Mitsumasa,Kinuya Seigo
Abstract
AbstractThe 123I-labeled meta-iodobenzylguanidine (MIBG) is an analogue of noradrenaline that can evaluate cardiac sympathetic activity in scintigraphy. Quantitative analysis of 123I-MIBG images has been verified in patients with heart failure and neurodegenerative diseases. However, quantitative results differ due to variations in scintigraphic imaging procedures. Here, we created and assessed the clinical feasibility of a calibration method for 123I-MIBG imaging. The characteristics of scintigraphic imaging systems were determined using an acrylic calibration phantom to generate a multicenter phantom imaging database. Calibration factors corresponding to the scintigraphic imaging procedures were calculated from the database and applied to a clinical study. The results of this study showed that the calibrated analysis eliminated inter-institutional differences among normal individuals. In summary, our standardization methodology for 123I-MIBG scintigraphy could provide the basis for improved diagnostic precision and better outcomes for patients.
Funder
Japan Society for the Promotion of Science
Grants for Promoted Research from Kanazawa Medical University
Publisher
Springer Science and Business Media LLC
Cited by
7 articles.
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