Author:
Zhao Yixiao,Hubbard Logan,Malkasian Shant,Abbona Pablo,Molloi Sabee
Abstract
AbstractThe purpose of this study is to develop and validate an optimal timing protocol for a low-radiation-dose CT pulmonary perfusion technique using only two volume scans. A total of 24 swine (48.5 ± 14.3 kg) underwent contrast-enhanced dynamic CT. Multiple contrast injections were made under different pulmonary perfusion conditions, resulting in a total of 141 complete pulmonary arterial input functions (AIFs). Using all the AIF curves, an optimal contrast timing protocol was developed for a first-pass, two-volume dynamic CT perfusion technique (one at the base and the other at the peak of AIF curve). A subset of swine was used to validate the prospective two-volume pulmonary perfusion technique. The prospective two-volume perfusion measurements were quantitatively compared to the previously validated retrospective perfusion measurements with t-test, linear regression, and Bland–Altman analysis. As a result, the pulmonary artery time-to-peak ($${T}_{PA}$$
T
PA
) was related to one-half of the contrast injection duration ($$\frac{{T}_{Inj}}{2}$$
T
Inj
2
) by $${T}_{PA}=1.01\frac{{T}_{Inj}}{2}+1.01$$
T
PA
=
1.01
T
Inj
2
+
1.01
(r = 0.95). The prospective two-volume perfusion measurements (PPRO) were related to the retrospective measurements (PRETRO) by PPRO = 0.87PRETRO + 0.56 (r = 0.88). The CT dose index and size-specific dose estimate of the two-volume CT technique were estimated to be 28.4 and 47.0 mGy, respectively. The optimal timing protocol can enable an accurate, low-radiation-dose two-volume dynamic CT perfusion technique.
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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