Abstract
AbstractPlants represents a huge source of bioactive materials that have been used since the old times in the treatment of many diseases. Balanites aegyptiaca, known as desert date, has been used in treatment of fever, diabetes and bacterial infection. Desert dates contains a hard seed that resembles 50–60% of the fruit. The seed extract contains many fatty acids, amino acids and other bioactive materials that gives the extract its antioxidant and anti-inflammatory properties. The study aimed to use Balanites seed extract-loaded chitosan nanoparticles (SeEx-C NPs) for the treatment of streptozotocin (STZ)-induced diabetes in male Sprague Dawley rats. Animals were divided into two main divisions (healthy and diabetic rats). Each division contained seven groups (5 rats/group): control untreated group I, SeEx treated group II and group III (10 and 20 mg/kg b.w., respectively), C NPs treated group IV and group V (10 and 20 mg/kg b.w., respectively) and SeEx-C NPs treated group VI and group VII (10 and 20 mg/kg b.w., respectively). The therapeutical effects of SeEx-C NPs were evaluated through biochemical and immunological assessments in rats’ pancreases. The results showed that SeEx-C NPs (10 and 20 mg/kg b.w.) reduced the oxidative stress and inflammation in rats’ pancreases allowing the islets neogenesis. The loading of SeEx on C NPs allowed the delivery of fatty acids (oleic, lauric and myristic acid), amino acids (lysine, leucine, phenylalanine and valine) and minerals to pancreatic beta-cells in a sustainable manner. SeEx-C NPs administration successfully increased insulin secretion, allowed pancreatic islets neogenesis and reduced oxidative stress and inflammation.
Publisher
Springer Science and Business Media LLC
Reference50 articles.
1. Farid, A., Haridyy, H., Ashraf, S., Ahmed, S. & Safwat, G. Co-treatment with grape seed extract and mesenchymal stem cells in vivo regenerated beta cells of islets of Langerhans in pancreas of type I-induced diabetic rats. Stem Cell Res. Ther. 13(1), 528 (2022).
2. Peyrot, M., Rubin, R. R., Kruger, D. E. & Travis, L. B. Correlates of insulin injection omission. Diabetes Care 33, 240–245 (2010).
3. Ogbera, A. O., Dada, O., Adeyeye, F. & Jewo, P. I. Complementary and alternative medicine use in diabetes mellitus. West Afr. J. Med. 29, 158–162 (2010).
4. Murthy, H. N., Yadav, G. G., Dewir, Y. H. & Ibrahim, A. Phytochemicals and biological activity of desert date (Balanites aegyptiaca (L.) Delile). Plants 10(1), 32 (2010).
5. Chothani, D. L. & Vaghasiya, H. U. A review on Balanites aegyptiaca Del (desert date): Phytochemical constituents, traditional uses, and pharmacological activity. Pharmacogn. Rev. 5(9), 55–62 (2011).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献