Evaluation of SPP1/osteopontin expression as predictor of recurrence in tamoxifen treated breast cancer

Author:

Göthlin Eremo AnnaORCID,Lagergren Kajsa,Othman Lana,Montgomery Scott,Andersson Göran,Tina Elisabet

Abstract

AbstractBreast cancer patients treated with tamoxifen may experience recurrence due to endocrine resistance, which highlights the need for additional predictive and prognostic biomarkers. The glyco-phosphoprotein osteopontin (OPN), encoded by the SPP1 gene, has previously shown to be associated with poor prognosis in breast cancer. However, studies on the predictive value of OPN are inconclusive. In the present study, we evaluated tissue SPP1 mRNA and OPN protein expression as markers of recurrence in estrogen receptor- positive (ER+) breast cancer tissue. Tamoxifen- treated patients with recurrence or non-recurrence were selected using a matched case-control design. SPP1 mRNA expression was analysed using qPCR (n = 100) and OPN protein by immunohistochemistry (n = 116) using different antibodies. Odds ratios were estimated with conditional logistic regression. The SPP1 expression increased the risk of recurrence with an odds ratio (OR) of 2.50 (95% confidence interval [CI]; 1.30–4.82), after adjustment for tumour grade, HER 2 status and other treatments to OR 3.62 (95% CI; 1.45–9.07). However, OPN protein expression was not associated with risk of recurrence or with SPP1-gene expression, suggesting SPP1 mRNA a stronger prognostic marker candidate compared to tumor tissue OPN protein.

Funder

Lions Cancer Research fund (Region Uppsala Örebro) Research committee, Region Örebro County ALF grants, Region Örebro County Swedish Cancer Society.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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