Electrochemical degradation and saponification of porcine adipose tissue

Author:

Pham Tiffany T.,Stokolosa Anna M.,Borden Pamela A.,Hansen Kyle D.,Hong Ellen M.,Krasieva Tatiana B.,Sivoraphonh Ryan H.,Moy Wesley J.ORCID,Heidari Andrew E.,Lee Lauren H.,Kim Eun-Hee,Sun Chung- Ho,Jia Wangcun,Mo Ji -Hun,Kim SehwanORCID,Hill Michael G.,Wong Brian J. F.

Abstract

AbstractBody contouring achieved via subcutaneous adipose tissue reduction has notably advanced over the past century, from suction assisted lipectomy to techniques with reduced degrees of invasiveness including laser, radiofrequency, high frequency focused ultrasound, cryolipolysis, and drug-based injection approaches. These costly techniques have focused on damaging adipocyte cell membranes, hydrolyzing triglycerides (TGs), or inducing apoptosis. Here, we present a simple, low-cost technique, termed electrochemical lipolysis (ECLL). During ECLL, saline is injected into the subcutaneous adipose tissue, followed by insertion of needle electrodes and application of an electrical potential. Electrolysis of saline creates localized pH gradients that drive adipocyte death and saponification of TGs. Using pH mapping, various optical imaging techniques, and biochemical assays, we demonstrate the ability of ECLL to induce acid and base injury, cell death, and the saponification of triglycerides in ex vivo porcine adipose tissue. We define ECLL’s potential role as a minimally-invasive, ultra-low-cost technology for reducing and contouring adipose tissue, and present ECLL as a potential new application of an emerging electrochemical redox based treatment modality.

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Irvine Head and Neck Foundation

National Research Foundation of Korea

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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