Author:
Hattori Kaoru,Nakama Natsuki,Takada Jumpei,Nishimura Gohki,Moriwaki Ryo,Kawasaki Eita,Nagao Michinobu,Goto Yasuhiro,Niinami Hiroshi,Iwasaki Kiyotaka
Abstract
AbstractThe characteristics of aortic valvular outflow jet affect aortopathy in the bicuspid aortic valve (BAV). This study aimed to elucidate the effects of BAV morphology on the aortic valvular outflow jets. Morphotype-specific valve-devising apparatuses were developed to create aortic valve models. A magnetic resonance imaging-compatible pulsatile flow circulation system was developed to quantify the outflow jet. The eccentricity and circulation values of the peak systolic jet were compared among tricuspid aortic valve (TAV), three asymmetric BAVs, and two symmetric BAVs. The results showed mean aortic flow and leakage did not differ among the five BAVs (six samples, each). Asymmetric BAVs demonstrated the eccentric outflow jets directed to the aortic wall facing the smaller leaflets. In the asymmetric BAV with the smaller leaflet facing the right-anterior, left-posterior, and left-anterior quadrants of the aorta, the outflow jets exclusively impinged on the outer curvature of the ascending aorta, proximal arch, and the supra-valvular aortic wall, respectively. Symmetric BAVs demonstrated mildly eccentric outflow jets that did not impinge on the aortic wall. The circulation values at peak systole increased in asymmetric BAVs. The bicuspid symmetry and the position of smaller leaflet were determinant factors of the characteristics of aortic valvular outflow jet.
Funder
Grants-in Aid for Scientific Research in Japan
Subsidy Program for the Development of International Standards for the Evaluation of Innovative Medical Devices and Regenerative Medicine Products, of the Ministry of Health, Labor and Welfare, Japan
Publisher
Springer Science and Business Media LLC
Cited by
12 articles.
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