Author:
Shin Minna,Kim Kiju,Lee Hyo-Ji,Lee Rangyeon,Jung Yu-Jin,Park Jeongho,Hahn Tae-Wook
Abstract
AbstractZika virus (ZIKV) is a mosquito-borne virus that has a high risk of inducing Guillain–Barré syndrome and microcephaly in newborns. Because vaccination is considered the most effective strategy against ZIKV infection, we designed a recombinant vaccine utilizing the baculovirus expression system with two strains of ZIKV envelope protein (MR766, Env_M; ZBRX6, Env_Z). Animals inoculated with Env_M and Env_Z produced ZIKV-specific antibodies and secreted effector cytokines such as interferon-γ, tumor necrosis factor-α, and interleukin-12. Moreover, the progeny of immunized females had detectable maternal antibodies that protected them against two ZIKV strains (MR766 and PRVABC59) and a Dengue virus strain. We propose that the baculovirus expression system ZIKV envelope protein recombinant provides a safe and effective vaccine strategy.
Publisher
Springer Science and Business Media LLC
Reference53 articles.
1. Dick, G. W., Kitchen, S. F. & Haddow, A. J. Zika virus. I. Isolations and serological specificity. Trans. R. Soc. Trop. Med. Hyg. 46(5), 509–520 (1952).
2. Cao-Lormeau, V. M. et al. Guillain–Barré syndrome outbreak associated with zika virus infection in French Polynesia: A case–control study. Lancet 387(10027), 1531–1539 (2016).
3. Cao-Lormeau, V. M. et al. Zika virus, French polynesia, South pacific, 2013. Emerg. Infect. Dis. 20(6), 1085–1086 (2014).
4. World Health Organization. Countries and Territories with Current or Previous Zika Virus Transmission. https://www.who.int/emergencies/diseases/zika/countries-with-zika-and-vectors-table.pdf (2019).
5. Slavov, S. N., Otaguiri, K. K., Kashima, S. & Covas, D. T. Overview of Zika virus (ZIKV) infection in regards to the Brazilian epidemic. Braz. J. Med. Biol. Res. 49(5), e5420 (2016).
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