Author:
Wu Jia-Feng,Hsu Wei-Chung,Tsai I.-Jung,Tong Tzu-Wei,Lin Yu-Cheng,Yang Chia-Hsiang,Tseng Ping-Huei
Abstract
AbstractLaryngopharyngeal reflux symptom is a troublesome upper esophageal problem, and reflux symptom index (RSI) is commonly applied for the assessment of clinical severity. We investigated the relationship between the upper esophageal sphincter impedance integral (UESII) and RSI scores in this study. Totally 158 subjects with high-resolution esophageal impedance manometry (HRIM) with RSI questionnaire assessment were recruited. There are 57 (36.08%), 74 (46.84%), 21 (13.29%), and 6 (3.79%) patients were categorized as normal, ineffective esophageal motility disorder, absent contractility, and achalasia by HRIM examination, respectively. Subjects with RSI > 13 were noted to have lower UESII than others with RSI ≦ 13 (7363.14 ± 1085.58 vs. 11,833.75 ± 918.77 Ω s cm; P < 0.005). The ROC analysis yielded a UESII cutoff of < 2900 Ω s cm for the best prediction of subjects with RSI > 13 (P = 0.002). Both female gender and UESII cutoff of < 2900 Ω s cm were significant predictors of RSI > 13 in logistic regression analysis (OR = 3.84 and 2.83; P = 0.001 and 0.01; respectively). Lower UESII on HRIM study, indicating poor bolus transit of UES during saline swallows, is significantly associated with prominent laryngopharyngeal reflux symptoms scored by RSI score.
Funder
Intelligent & Sustainable Medical Electronics Research Fund in National Taiwan University
National Taiwan University Hospital
Publisher
Springer Science and Business Media LLC
Reference26 articles.
1. Carlson, D. A. et al. High-resolution impedance manometry parameters enhance the esophageal motility evaluation in non-obstructive dysphagia patients without a major Chicago Classification motility disorder. Neurogastroenterol. Motil. 29, e12941 (2017).
2. Singendonk, M. M. J. et al. Novel pressure-impedance parameters for evaluating esophageal function in pediatric achalasia. J. Pediatr. Gastroenterol. Nutr. 66, 37–42 (2018).
3. Belafsky, P. C., Postma, G. N. & Koufman, J. A. Validity and reliability of the reflux symptom index (RSI). J. Voice 16, 274–277 (2002).
4. Nacci, A. et al. Reflux Symptom Index (RSI) and Singing Voice Handicap Index (SVHI) in singing students: A pilot study. J. Voice S0892–1997(20), 30171–30175 (2020).
5. Tseng, W. H. et al. Double-blind, placebo-controlled study with alginate suspension for laryngopharyngeal reflux disease. Laryngoscope 128, 2252–2260 (2018).
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