Real-time quality control of dripping pill’s weight based on laser detection technology-Reference-Cited by-同舟云学术

Real-time quality control of dripping pill’s weight based on laser detection technology

Published:2023-04-15 Issue:1 Volume:13 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Wang Xiaoping,Chen Hang,Tian Ying,Qu Haibin^ORCID

Abstract

AbstractThe present work reports developing the first process analytical technology (PAT)-based real-time feedback control system for maintaining the Ginkgo biloba leaf dripping pills weight during manufacturing. The opening degree of the drop valve and the weight of dripping pills were chosen as the manipulated variable and as the controlled variable, respectively. A proportional-integral controller was programmed to automatically reach the desired dripping pills weight by adjusting the opening degree of the drop valve. The closed-loop feedback control system could automatically compensate for the disturbances and ensure a predefined weight of the dripping pills with excellent robustness, high accuracy, and high efficiency during manufacturing. Furthermore, the closed-loop feedback control system improved the process capability of the dripping process, and the process capability index was > 1.67. This study provides a new approach to real-time control of the weight of dripping pills and improves the process capability during Ginkgo biloba leaf dripping pills manufacturing.

Funder

Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine

Science and Technology Program of Zhejiang Province of China

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41598-023-32805-z.pdf

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