Author:
Pincus Alexandra B.,Huang Samuel J.,Lebold Katie M.,De La Torre Ubaldo,Proskocil Becky J.,Drake Matthew G.,Nakai Hiroyuki,Fryer Allison D.,Jacoby David B.
Abstract
AbstractWe report subpopulations of airway parasympathetic neurons expressing substance P, neuronal nitric oxide synthase, and tyrosine hydroxylase, highlighting unexplored heterogeneity in this population. These neurotransmitter-specific subpopulations did not form intraganglionic interneurons, but rather, extended outside the ganglia, into the airways, to distant innervation targets. Our experiments demonstrate the utility of multicolor labeling to characterize airway innervation, allowing us to confirm the extensive heterogeneity of postganglionic parasympathetic neurons. These methods will facilitate future investigations of neurophysiology and neural contributions to airway disease.
Funder
National Heart, Lung, and Blood Institute
National Institute of Allergy and Infectious Diseases
Publisher
Springer Science and Business Media LLC
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献