Author:
Sahilu Tamiru,Getachew Mestawet,Melaku Tsegaye,Sheleme Tadesse,Abu Duresa,Zewdu Tesfu
Abstract
AbstractPotential adverse drug event (PADE) is a medication error with the potential to cause associate degree injury however that does not cause any injury, either due to specific circumstances, chance, or as a result of the error being intercepted and corrected. This study aimed to assess the incidence, contributing factors, predictors, severity, and preventability of PADEs among hospitalized adult patients at Jimma Medical Center. A prospective observational study was conducted among hospitalized adult patients at a tertiary hospital in Ethiopia. Logistic regression was performed to identify factors predicting PADE occurrence. P-value < 0.05 was considered for statistical significance. A total of 319 patients were included. About 50.5% of them were females. The mean ± SD age of the participants was 43 ± 17.6 years. Ninety-four PADEs were identified. Number of medications (adjusted OR = 5.12; 95% CI: 2.01–13.05; p = 0.001), anticoagulants (adjusted OR = 2.51; 95% CI: 1.22–5.19; p = 0.013), anti-seizures (adjusted OR = 21.96; 95% CI: 6.57–73.39; p < 0.0001), anti-tuberculosis (adjusted OR = 2.2; 95% CI: 1.002–4.59, p = 0.049), and Elixhauser comorbidity Index ≤ 15 (adjusted OR = 6.24; 95% CI: 1.48–26.25, p = 0.013) were independent predictors of PADEs occurrence. About one-third of patients admitted to the hospital experienced PADEs.
Publisher
Springer Science and Business Media LLC
Reference37 articles.
1. Gates, P. J., Baysari, M. T., Mumford, V., Raban, M. Z. & Westbrook, J. I. Standardising the classification of harm associated with medication errors: The harm associated with medication error classification (HAMEC). Drug Saf. 42(8), 931–939 (2019).
2. Donaldson, L. J., Kelley, E. T., Dhingra-Kumar, N., Kieny, M.-P. & Sheikh, A. Medication without harm: WHO’s third global patient safety challenge. Lancet 389(10080), 1680–1681 (2017).
3. National Coordinating Council for Medication Error Reporting and Prevention (NCCMERP). Definition and Types of Medication Errors. http://www.nccmerp.org/about-medication-errors. Accessed 09 Feb 2019.
4. Dedefo, M. G., Mitike, A. H. & Angamo, M. T. Incidence and determinants of medication errors and adverse drug events among hospitalized children in West Ethiopia. BMC Pediatr. 16(81), 016–0619 (2016).
5. World Health Organization. 10 Facts on Patient Safety. https://www.who.int/features/factfiles/patient_safety/en/ Accessed 16 Jan 2019.