Author:
Mukherjee Pradipta,Miyazawa Arata,Fukuda Shinichi,Yamashita Toshiharu,Lukmanto Donny,Okada Kosuke,El-Sadek Ibrahim Abd,Zhu Lida,Makita Shuichi,Oshika Tetsuro,Yasuno Yoshiaki
Abstract
AbstractWe demonstrate label-free imaging of the functional and structural properties of microvascular complex in mice liver. The imaging was performed by a custom-built Jones-matrix based polarization sensitive optical coherence tomography (JM-OCT), which is capable of measuring tissue’s attenuation coefficient, birefringence, and tiny tissue dynamics. Two longitudinal studies comprising a healthy liver and an early fibrotic liver model were performed. In the healthy liver, we observed distinctive high dynamics beneath the vessel at the initial time point (0 h) and reappearance of high dynamics at 32-h time point. In the early fibrotic liver model, we observed high dynamics signal that reveals a clear network vascular structure by volume rendering. Longitudinal time-course imaging showed that these high dynamics signals faded and decreased over time.
Funder
Japan Science and Technology Agency
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Cited by
10 articles.
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