Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-37102-8.pdf
Reference79 articles.
1. The Huntington’s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell 72, 971–983 (1993).
2. Bates, G., Tabrizi, S. & Jones, L. Eds Huntington’s disease 4th Edn. (Oxford Univ. Press, Oxford, 2014).
3. Williams, G. C. Pleiotropy natural selection, and the evolution of senescence. Evolution 11, 398–411 (1957).
4. Albin, R. L. The pleiotropic gene theory of senescence: supportive evidence from human genetic disease. Ethol. Sociobiol. 9, 371–382 (1988).
5. Medawar, P. An Unsolved Problem of Biology. (Lewis, H. K. & Co., London, 1970).
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