Author:
Yu Jiyon,Choi Yoon Jeong,Choi Sung-Hwan,Jung Han-Sung,Lee Ji Hyun,Cha Jung-Yul
Abstract
AbstractTo elucidate genetic factors affecting orthodontic treatment duration, we employed targeted next-generation sequencing on DNA from the saliva of 117 patients undergoing orthodontic treatment after premolar extraction. The clinical characteristics of patients are summarized, and the association of clinical variables with treatment duration was assessed. Patients whose treatment duration deviated from the average were classified into an extreme long group or an extreme short group. We identified nine single nucleotide polymorphisms (SNPs) of six genes that significantly differed in the two groups via targeted sequencing. The frequency of the CC genotypes of WNT3A, SPP1 (rs4754, rs9138), and TNFSF11, TT genotype of SPP1 (rs1126616), and GG genotype of SFRP2 was significantly higher in the extreme long group than in the short group. In the extreme short group, the TC genotype of SPP1, AA genotype of P2RX7, CT genotype of TNFSF11, and AG genotype of TNFRSF11A tended to exhibit higher frequency than in the long group. Taken together, we identified genetic polymorphisms related to treatment duration in Korean orthodontic patients undergoing premolar extraction. Our findings could lead to further studies predicting the prolongation of the orthodontic treatment duration, and will be of great aid to patients as well as orthodontists.
Publisher
Springer Science and Business Media LLC
Reference45 articles.
1. Pachêco-Pereira, C., Pereira, J. R., Dick, B. D., Perez, A. & Flores-Mir, C. Factors associated with patient and parent satisfaction after orthodontic treatment: A systematic review. Am. J. Orthod. Dentofac. Orthop. 148(4), 652–659 (2015).
2. Beckwith, F. R., Ackerman, R. J. Jr., Cobb, C. M. & Tira, D. E. An evaluation of factors affecting duration of orthodontic treatment. Am. J. Orthod. Dentofac. Orthop. 115(4), 439–447 (1999).
3. Dyer, G., Harris, E. & Vaden, J. Age effects contrasted on orthodontic with adults treatment: Adolescents. Am. J. Orthod. Dentofac. Orthop. 100(6), 523–530 (1991).
4. Skidmore, K. J., Brook, K. J., Thomson, W. M. & Harding, W. J. Factors influencing treatment time in orthodontic patients. Am. J. Orthod. Dentofac. Orthop. 129(2), 230–238 (2006).
5. Haralabakis, N. B. & Tsiliagkou, K. The effect of six variables and their interrelation on the duration of orthodontic treatment. Hellenic Orthod. Rev. 7(1), 45–57 (2004).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献