Author:
Hsu Chia-Wei,Yang An-Cheng,Kung Pei-Ching,Tsou Nien-Ti,Chen Nan-Yow
Abstract
AbstractEngineering simulation accelerates the development of reliable and repeatable design processes in various domains. However, the computing resource consumption is dramatically raised in the whole development processes. Making the most of these simulation data becomes more and more important in modern industrial product design. In the present study, we proposed a workflow comprised of a series of machine learning algorithms (mainly deep neuron networks) to be an alternative to the numerical simulation. We have applied the workflow to the field of dental implant design process. The process is based on a complex, time-dependent, multi-physical biomechanical theory, known as mechano-regulatory method. It has been used to evaluate the performance of dental implants and to assess the tissue recovery after the oral surgery procedures. We provided a deep learning network (DLN) with calibrated simulation data that came from different simulation conditions with experimental verification. The DLN achieves nearly exact result of simulated bone healing history around implants. The correlation of the predicted essential physical properties of surrounding bones (e.g. strain and fluid velocity) and performance indexes of implants (e.g. bone area and bone-implant contact) were greater than 0.980 and 0.947, respectively. The testing AUC values for the classification of each tissue phenotype were ranging from 0.90 to 0.99. The DLN reduced hours of simulation time to seconds. Moreover, our DLN is explainable via Deep Taylor decomposition, suggesting that the transverse fluid velocity, upper and lower parts of dental implants are the keys that influence bone healing and the distribution of tissue phenotypes the most. Many examples of commercial dental implants with designs which follow these design strategies can be found. This work demonstrates that DLN with proper network design is capable to replace complex, time-dependent, multi-physical models/theories, as well as to reveal the underlying features without prior professional knowledge.
Funder
Ministry of Science and Technology, Taiwan
Publisher
Springer Science and Business Media LLC
Reference35 articles.
1. Cooper, J., Vik, J. O. & Waltemath, D. A call for virtual experiments: Accelerating the scientific process. Prog. Biophys. Mol. Biol. 117, 99–106 (2015).
2. LeCun, Y., Bengio, Y. & Hinton, G. Deep learning. Nature 521, 436–444 (2015).
3. Simonyan, K. &Zisserman, A. Very deep convolutional networks for large-scale image recognition. in 3rd International Conference on Learning Representations, ICLR 2015-Conference Track Proceedings (2015).
4. Silver, D. et al. Mastering the game of Go with deep neural networks and tree search. Nature 529, 63 (2016).
5. Iglovikov, V. I., Rakhlin, A., Kalinin, A. A. &Shvets, A. A. Paediatric bone age assessment using deep convolutional neural networks. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 11045. LNCS 300–308 (Springer, 2018).
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