Author:
Feu-Basilio Silvia,Maloca Peter M.,Hasler Pascal,Scholl Hendrik P. N.,Marin-Martinez Sara,Rosinés-Fonoll Josep,Suarez-Valero Xavier,Reich Michael,Lange Clemens,Egan Catherine,Zweifel Sandrine,Tufail Adnan,Spaide Richard F.,Zarranz-Ventura Javier
Abstract
AbstractOptical coherence tomography angiography (OCTA) enables three-dimensional reconstruction of the functional blood vessels in the retina. Therefore, it enables the quantification of 3D retinal vessel parameters such as surface area and vessel volume. In spite of the widespread use of OCTA, no representative volume-rendered vessel volume (VV) data are published to date. In this study, OCTA 3 × 3 mm macular cubes were processed with volume-rendering techniques to measure VV in 203 eyes from 107 healthy volunteers. Generalized linear models (GLM) were constructed to assess the impact of age, gender, visual acuity (VA), spherical equivalent (SE), and axial length (AL) on VV. Overall mean VV was 0.23 ± 0.05mm3. Age and axial length showed a negative correlation with VV. However, GLM model analysis found that AL exerted the most pronounced influence on VV. No statistically significant associations were identified between gender or between left and right eyes. This is the first study to assess 3D OCTA VV and its naturally occurring variations in a large series of healthy subjects. It offers novel insights into the characterization of normal retinal vascular anatomy in healthy individuals, contributing to a valuable reference for future research in this field.
Funder
This study has been funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union.
Publisher
Springer Science and Business Media LLC