CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens-Reference-Cited by-同舟云学术

CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens

Published:2017-10-12 Issue:1 Volume:7 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Ishii Tsuyoshi,Okai Takuro,Iwatani-Yoshihara Misa,Mochizuki Manabu,Unno Satoko,Kuno Masako,Yoshikawa Masato,Shibata Sachio,Nakakariya Masanori,Yogo Takatoshi,Kawamoto Tomohiro

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-017-12513-1.pdf

Reference39 articles.

1. Waring, M. J. et al. An analysis of the attrition of drug candidates from four major pharmaceutical companies. Nat. Rev. Drug Discov. 14, 475–486 (2015).

2. Morgan, P. et al. Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival. Drug Discov. Today 17, 419–424 (2012).

3. Bunnage, M. E., Chekler, E. L. & Jones, L. H. Target validation using chemical probes. Nat. Chem. Biol. 9, 195–199 (2013).

4. Jafari, R. et al. The cellular thermal shift assay for evaluating drug target interactions in cells. Nat Protoc 9, 2100–2122 (2014).

5. Martinez Molina, D. et al. Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay. Science 341, 84–87 (2013).

Cited by 46 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent advances in protein precipitation-based methods for drug-target screening;Chinese Journal of Chromatography;2024-07-01

2. Development of Biochemical and Cellular Probes to Study RIPK1 Target Engagement;ACS Medicinal Chemistry Letters;2024-05-10

3. Innovative strategies for measuring kinase activity to accelerate the next wave of novel kinase inhibitors;Drug Discovery Today;2024-03

4. ReBaTSA: A simplified CeTSA protocol for studying recombinant mutant proteins in bacterial extracts;Biochimica et Biophysica Acta (BBA) - General Subjects;2024-02

5. Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies;Cell Death & Differentiation;2024-01-18