Author:
See Jermyn Z.,Homma Natsumi Y.,Atencio Craig A.,Sohal Vikaas S.,Schreiner Christoph E.
Abstract
AbstractNeuronal activity in auditory cortex is often highly synchronous between neighboring neurons. Such coordinated activity is thought to be crucial for information processing. We determined the functional properties of coordinated neuronal ensembles (cNEs) within primary auditory cortical (AI) columns relative to the contributing neurons. Nearly half of AI cNEs showed robust spectro-temporal receptive fields whereas the remaining cNEs showed little or no acoustic feature selectivity. cNEs can therefore capture either specific, time-locked information of spectro-temporal stimulus features or reflect stimulus-unspecific, less-time specific processing aspects. By contrast, we show that individual neurons can represent both of those aspects through membership in multiple cNEs with either high or absent feature selectivity. These associations produce functionally heterogeneous spikes identifiable by instantaneous association with different cNEs. This demonstrates that single neuron spike trains can sequentially convey multiple aspects that contribute to cortical processing, including stimulus-specific and unspecific information.
Funder
National Institutes of Health
Publisher
Springer Science and Business Media LLC
Reference52 articles.
1. Braitenberg, V. & Schüz, A. Anatomy of the Cortex Vol. 18 (Springer, Berlin, 1991).
2. Bathellier, B., Ushakova, L. & Rumpel, S. Discrete neocortical dynamics predict behavioral categorization of sounds. Neuron 76, 435–449 (2012).
3. Gulati, T., Ramanathan, D. S., Wong, C. C. & Ganguly, K. Reactivation of emergent task-related ensembles during slow-wave sleep after neuroprosthetic learning. Nat. Neurosci. 17, 1107–1113 (2014).
4. Kiani, R., Cueva, C. J., Reppas, J. B. & Newsome, W. T. Dynamics of neural population responses in prefrontal cortex indicate changes of mind on single trials. Curr. Biol. 24, 1542–1547 (2014).
5. Jacobs, N. S., Chen-Bee, C. H. & Frostig, R. D. Emergence of spatiotemporal invariance in large neuronal ensembles in rat barrel cortex. Front. Neural Circ. 9, 1–16 (2015).
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