Author:
Brilliant T. Denilson,Takeuchi Hikaru,Nouchi Rui,Yokoyama Ryoichi,Kotozaki Yuka,Nakagawa Seishu,Hanawa Sugiko,Sekiguchi Atsushi,Ikeda Shigeyuki,Sakaki Kohei,Kawata Kelssy Hitomi dos Santos,Nozawa Takayuki,Yokota Susumu,Magistro Daniele,Kawashima Ryuta
Abstract
AbstractAlthough loneliness itself is a natural emotion, prolonged loneliness is detrimental to human health. Despite its detrimental effect, few loneliness-related neuroimaging studies have been published and some have limitations on the sample size number. This study aims to find the difference in resting-state functional connectivity associated with loneliness within a big sample size via the seed-based approach. Functional connectivity analysis was performed on a large cohort of young adults (N = 1336) using the seed-based functional connectivity approach to address the concern from previous studies. The analysis yielded statistically significant positive correlations between loneliness and functional connectivities between the inferior frontal gyrus and supplementary motor area, precentral gyrus, and superior parietal lobule. Additionally, the analysis replicated a finding from a previous study, which is increased functional connectivities between the inferior frontal gyrus and supplementary motor area. In conclusion, greater loneliness is reflected by stronger functional connectivity of the visual attention brain area.
Funder
Japan Society for the Promotion of Science
Publisher
Springer Science and Business Media LLC
Cited by
7 articles.
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