Virulence factors, antibiotic susceptibility and sequence type distribution of hospital-associated Clostridioides difficile isolates in Israel, 2020

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Virulence factors, antibiotic susceptibility and sequence type distribution of hospital-associated Clostridioides difficile isolates in Israel, 2020–2022

Published:2024-09-04 Issue:1 Volume:14 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Schwartz Orna,Rohana Hanan,Azrad Maya,Shor Anna,Rainy Nir,Maor Yasmin,Nesher Lior,Sagi Orli,Peretz Avi

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41598-024-71492-2.pdf

Reference41 articles.

1. Lee, H. S., Plechot, K., Gohil, S. & Le, J. Clostridium difficile: Diagnosis and the consequence of over diagnosis. Infect. Dis. Ther. 10, 687–697. https://doi.org/10.1007/s40121-021-00417-7 (2021).

2. Rea, M. C. et al. Clostridium difficile carriage in elderly subjects and associated changes in the intestinal microbiota. J. Clin. Microbiol. 50, 867–875 (2012).

3. Cho, H. J. et al. Epidemiology and clinical characteristics of Clostridium difficile -associated disease in children: Comparison between community- and hospital-acquired infections. Korean J. Pediatr. Gastroenterol. Nutr. 13, 146 (2010).

4. Calatayud, M. et al. Long-term lactulose administration improves dysbiosis induced by antibiotic and C. difficile in the PathoGutTM SHIME model. Antibiotics 11, 1464 (2022).

5. Sacco, M. D. et al. A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nat. Commun. 13, 4370 (2022).

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