Author:
Jiang Lingling,Liu Boyang,Qi Yan,Zhu Linru,Cui Xueling,Liu Zhonghui
Abstract
AbstractFibroblasts play an important role in inflammation and tissue fibrosis. Both activin A and TNF-α can activate immune cells, however, the roles and relationship of them in activating fibroblasts in inflammation remain unclear. Here, this study revealed that TNF-α promoted the release of NO and IL-6 by L929 fibroblast cells, but co-treatment with activin A attenuated these effects. In contrast, activin A induced cell migration and increased the production of tissue fibrosis-related TGF-β1 and fibronectin, while TNF-α inhibited these function changes of L929 cells induced by activin A. Moreover, this study revealed that activin A and TNF-α regulated the activities of L929 cells via ERK1/2/MAPK pathway, rather than Smad3-dependent signaling pathway. Taken together, these data indicate that activin A and TNF-α exert mutually antagonistic effects on regulating fibroblasts activities, and the balance between their action may determine the process and outcome of fibroblasts-mediated inflammation.
Funder
Department of Finance of Jilin Province
Science Foundation of Jilin Province
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Reference51 articles.
1. Buechler, M. B. & Turley, S. J. A short field guide to fibroblast function in immunity. Semin. Immunol. 35, 48–58 (2018).
2. Owens, B. M. et al. Corrigendum: CD90(+) stromal cells are non-professional innate immune effectors of the human colonic mucosa. Front. Immunol. 6, 325 (2015).
3. Nguyen, H. N. et al. Autocrine loop involving IL-6 family member LIF, LIF receptor, and STAT4 drives sustained fibroblast production of inflammatory mediators. Immunity 46, 220–232 (2017).
4. DiPietro, L. A. Angiogenesis and wound repair: When enough is enough. J. Leukoc. Biol. 100, 979–984 (2016).
5. Moller, D. E. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab. 11, 212–217 (2000).
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