Insights into the mechanism of the PIK3CA E545K activating mutation using MD simulations
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-27044-6.pdf
Reference64 articles.
1. Cantley, L. C. The phosphoinositide 3-kinase pathway. Science 296, 1655–1657, https://doi.org/10.1126/science.296.5573.1655 (2002).
2. Yuan, T. L. & Cantley, L. C. PI3K pathway alterations in cancer: variations on a theme. Oncogene 27, 5497–5510, https://doi.org/10.1038/onc.2008.245 (2008).
3. Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554, https://doi.org/10.1126/science.1096502 (2004).
4. Ikenoue, T. et al. Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 65, 4562–4567, https://doi.org/10.1158/0008-5472.CAN-04-4114 (2005).
5. Isakoff, S. J. et al. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 65, 10992–11000, https://doi.org/10.1158/0008-5472.CAN-05-2612 (2005).
Cited by 44 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Free energy landscape of the PI3Kα C-terminal activation;Computational and Structural Biotechnology Journal;2024-12
2. The Study of PIK3CA Hotspot Mutations and Co-Occurring with EGFR, KRAS, and TP53 Mutations in Non-Small Cell Lung Cancer;OncoTargets and Therapy;2024-09
3. Depicting Biomarkers for HER2-Inhibitor Resistance: Implication for Therapy in HER2-Positive Breast Cancer;Cancers;2024-07-24
4. The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients: the challenge is open for new therapeutic strategies;Critical Reviews in Oncology/Hematology;2024-04
5. Rare subclonal sequencing of breast cancers indicates putative metastatic driver mutations are predominately acquired after dissemination;Genome Medicine;2024-02-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3