Association of Toll-like receptors polymorphisms with the risk of acute lymphoblastic leukemia in the Brazilian Amazon

Author:

Xabregas Lilyane Amorim,Hanna Fabíola Silva Alves,Magalhães-Gama Fábio,Souza Gláucia Lima,Pereira Daniele Sá,de Lima Amanda Barros,Toro Diana Mota,Santiago Mirian Rodrigues Ribeiro,da Motta Passos Leny Nascimento,Tarragô Andréa Monteiro,Malheiro Adriana,Costa Allyson Guimarães

Abstract

AbstractAcute lymphoblastic leukemia (ALL) is the most common hematologic malignancy in children in childhood. Single-nucleotide polymorphism (SNPs) in key molecules of the immune system, such as Toll-like receptors (TLRs) and CD14 molecules, are associated with the development of several diseases. However, their role in ALL is unknown. A case–control study was performed with 152 ALL patients and 187 healthy individuals to investigate the role of SNPs in TLRs and the CD14 gene in ALL. In this study, TLR6 C > T rs5743810 [OR: 3.20, 95% CI: 1.11–9.17, p = 0.003) and TLR9 C > T rs187084 (OR: 2.29, 95% CI: 1.23–4.26, p = 0.000) seems to be a risk for development of ALL. In addition, the TLR1 T > G rs5743618 and TLR6 C > T rs5743810 polymorphisms with protection against death (OR: 0.17, 95% IC: 0.04–0.79, p = 0.008; OR: 0.48, 95% IC: 0.24–0.94, p = 0.031, respectively). Our results show that SNPs in TLRs genes may be involved in the pathogenesis of ALL and may influence clinical prognosis; however, further studies are necessary to elucidate the role of TLR1, TLR4, TLR5, TLR6, TLR9 and CD14 polymorphisms in this disease.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado do Amazonas

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference55 articles.

1. Ferlay, J. et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int. J. Cancer 136, E359–E386 (2015).

2. Instituto Nacional do Câncer. Estimatida de câncer para o triênio 2020–2022. in Inca 122 (2020).

3. Alves, S. et al. Acute lymphoid and myeloid leukemia in a Brazilian Amazon population: Epidemiology and predictors of comorbidity and deaths. PLoS ONE 14, 1–16 (2019).

4. Bethesda. Childhood Acute Lymphoblastic Leukemia Treatment (PDQ(R)): Health Professional Version, in PDQ Cancer Information Summaries. (2020).

5. Zuckerman, T. & Rowe, J. Pathogenesis and prognostication in acute lymphoblastic leukemia. F1000Prime Rep. 6, 3–7 (2014).

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