Author:
Zhang Lulu,Xiao Yue,Yang Ruijie,Wang Siyi,Ma ShuangXin,Liu Jianling,Xiao Wei,Wang Yonghua
Abstract
AbstractBecause of the complex etiology, the treatment of gastric cancer is a formidable challenge for contemporary medical. The current treatment method focuses on traditional surgical procedures, supplemented by other treatments. Among these other treatments, Traditional Chinese Medicine (TCM) plays an important role. Here, we used the systems pharmacology approach to reveal the potential molecular mechanism of PRGRC on gastric cancer which composes of Pinellia ternata(Thunb.) Breit., Rheum palmatumL., Gentiana scabraBunge, Radix Aucklandiae and Citrus aurantium L. This approach combines pharmacokinetics analysis with pharmacodynamics evaluation for the active compounds screening, targets prediction and pathways assessing. Firstly, through pharmacokinetic evaluation and target prediction models, 83 potential compounds and 184 gastric cancer-related targets were screened out. Then, the results of network analysis suggested that the targets of PRGRC were mainly involved two aspects: apoptosis and inflammation. Finally, we verified the reliability of the above analysis at the cellular level by using naringenin and luteolin with good pharmacokinetic activity as representative compounds. Overall, we found that PRGRC could influence the development of gastric cancer from a multi-scale perspective. This study provided a new direction for analyzing the mechanism of TCM.
Funder
the Key project of Science and Technology Department of Shaanxi Province
National Science and Technology Major Project
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Reference55 articles.
1. Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71(3), 209–249 (2021).
2. He, P. et al. Hesperetin promotes cisplatin—Induced apoptosis of gastric cancer in vitro and in vivo by upregulating PTEN expression. Front. Pharmacol. 11, 1326 (2020).
3. Huang, W.-J. et al. Multidrug resistance of gastric cancer: The mechanisms and Chinese medicine reversal agents. Cancer Manage. Res. 12, 12385 (2020).
4. Cui, Y.-G. et al. Extraction process of ginger Pinellia and its anti-proliferative and proapoptotic activities on human gastric cancer SGC7901 cells. Biomed. Res. 27(1), 0970 (2016).
5. Yang, X. et al. Fuzheng Jiedu Xiaoji formulation inhibits hepatocellular carcinoma progression in patients by targeting the AKT/CyclinD1/p21/p27 pathway. Phytomedicine 87, 153575 (2021).
Cited by
14 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献