GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease-Reference-Cited by-同舟云学术

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease

Published:2019-06-10 Issue:1 Volume:9 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Schneider Jay S.,Aras Radha,Williams Courtney K.,Koprich James B.,Brotchie Jonathan M.,Singh Vikrant

Funder

Qilu Pharmaceutical Co., Ltd.

Qilu Pharmaceuticals, Inc.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-019-42847-x.pdf

Reference48 articles.

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2. Schneider, J. S. Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson’s disease. PLoS One 13, e0199189, https://doi.org/10.1371/journal.pone.0199189 (2018).

3. Seyfried, T. N. et al. Sex-related abnormalities in substantia nigra lipids in Parkinson’s disease. ASN Neuro 10, 1759091418781889, https://doi.org/10.1177/1759091418781889 (2018).

4. Wu, G., Lu, Z.-H., Kulkarni, N. & Ledeen, R. W. Deficiency of ganglioside GM1 correlates with Parkinson’s disease in mice and humans. Journal of Neuroscience Research 90, 1997–2008, https://doi.org/10.1002/jnr.23090 (2012).

5. Hadaczek, P. et al. GDNF signaling implemented by GM1 ganglioside; failure in Parkinson’s disease and GM1-deficient murine model. Experimental neurology 263, 177–189, https://doi.org/10.1016/j.expneurol.2014.10.010 (2015).

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