Author:
Siriwibool Siriwalee,Kaekratoke Nantawat,Chansaenpak Kantapat,Siwawannapong Kittipan,Panajapo Pannipa,Sagarik Kritsana,Noisa Parinya,Lai Rung-Yi,Kamkaew Anyanee
Abstract
AbstractWe developed a pH dependent amino heptamethine cyanine based theranostic probe (I2-IR783-Mpip) that can be activated by near infrared light. I2-IR783-Mpip, in acidic condition, exhibited an intense, broad NIR absorption band (820–950 nm) with high singlet oxygen generation upon exposure to NIR light (~850 nm). Theoretical calculations showed that the protonation of the probe in an acidic environment decreased the molecular orbital energy gaps and increased the intramolecular charge transfer efficiency. I2-IR783-Mpip exhibited good photodynamic efficiency towards liver hepatocellular carcinoma cells under physiological and slightly acidic conditions while normal human embryonic kidney cells remained alive under the same conditions. Detection of intracellular reactive oxygen species (ROS) in cells treated with I2-IR783-Mpip after NIR light exposure confirmed PDT efficiency of the probe in acidic environment. Moreover, I2-IR783-Mpip also demonstrated efficient phototoxicity under deep-seated tumour cell system. We believed this is the first PDT agent that possesses intrinsic tumour binding and selectively eradicate tumour in acidic environment under 850 nm NIR lamp.
Funder
Thailand Graduate Institute of Science and Technology
Thailand Research Fund
Publisher
Springer Science and Business Media LLC
Cited by
53 articles.
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