The genomic landscape of malignant peripheral nerve sheath tumors: diverse drivers of Ras pathway activation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-15183-1.pdf
Reference22 articles.
1. Evans, D. G. et al. Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet 39, 311–314 (2002).
2. Verdijk, R. M. et al. TP53 mutation analysis of malignant peripheral nerve sheath tumors. J Neuropathol Exp Neurol 69, 16–26, https://doi.org/10.1097/NEN.0b013e3181c55d55 (2010).
3. Nielsen, G. P. et al. Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. Am J Pathol 155, 1879–1884, https://doi.org/10.1016/S0002-9440(10)65507-1 (1999).
4. De Raedt, T. et al. PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature 514, 247–251, https://doi.org/10.1038/nature13561 (2014).
5. Zhang, M. et al. Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors. Nat Genet 46, 1170–1172, https://doi.org/10.1038/ng.3116 (2014).
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